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October 23, 2001


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Introduction
Long-term Protection
Rats We're Human . . .

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New Vaccine Sends Nicotine's Pleasurable Effects Up In Smoke

Long-term Protection

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Based on the way other vaccines work, the nicotine-specific antibodies from this one have the potential to remain in the circulatory system for a period of years, says David H. Malin, PhD, professor of psychology and neuroscience at University of Houston, Clear Lake, Texas. He, along with Dr. Fattom, Dr. Pentel and others, recently published a paper on the new vaccine.

If someone who's vaccinated decides to light up a year or two after kicking the habit, for example, the mood-enhancing properties of a cigarette are likely to be diminished or absent. "There is at least the possibility that a smoker who backslides may be disappointed," Dr. Malin said. "It might feel like they are just smoking burning paper."

Although a vaccine like this might seem like the smokers' equivalent of the alcohol deterrent Antabuse (generic name disulfiram) for alcoholics, Antabuse often actually makes drinkers a bit ill. NicVAX probably works for nicotine addiction as the drug naltrexone (ReVia) does for alcohol abuse: It just takes away the pleasurable feelings, Dr. Malin says.

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